Hairy cell leukemia case study

Benzene is an aromatic hydrocarbon used as a solvent. It is a clear liquid with a sweet odor. Origin of the substance:

Hairy cell leukemia case study

Hairy cell leukemia HCL is a chronic B-lineage lymphoproliferative disorder that was initially described by Bouroncle and coworkers in 1. The normal cellular counterpart of the hairy cell has not been identified, but immunologic 3molecular genetics 4 and chromosomal studies 5 show that it is of B-cell origin.

Types of lymphoma

Patients present with abdominal discomfort, which is related to splenomegaly, or - as in this patient - with fatigue, easy bruising and infection, which is related to anemia, thrombocytopenia, neutropenia, and monocytopenia.

Sometimes HCL is found incidentally during investigation of an unrelated medical problem. Most patients are pancytopenic at the time of the diagnosis 6. Clinical manifestations secondary to various autoimmune disorders are being recognized with increasing frequency in patients with HCL 7.

More unusual clinical manifestations are peripheral lymphadenopathy, lytic bone lesions, skin involvement, splenic rupture, and other organ involvement 8. The most characteristic laboratory finding is pancytopenia - as seen in this patient - which is followed by isolated neutropenia, Hairy cell leukemia case study, anemia, or monocytopenia.

Leucocytosis can also occur, but rarely. Hairy cells are present in the bone marrow and often in the peripheral blood 9. The cells are mononuclear with relatively abundant cytoplasm and a cell diameter in the range of 10 to 25 micrometers.

The cytoplasm is pale, blue-gray, and agranular, with variable numbers of elongated hairy projections. The nuclei are either round, oval, reniform, or dumbbell-shaped, with a nuclear chromatin pattern that is homogenous and less clumped, and lighter staining than that of mature lymphocytes and those seen in classic chronic lymphocytic leukemia and prolymphocytic leukemia.

A prominent nucleolus is rarely seen. A useful diagnostic test is the tartrate resistant acid phosphatase activity TRAP. Such activity is rare, but not unknown in other lymphoproliferative disorders. The bone marrow is usually difficult to aspirate as a consequence of fibrosis 10as was the case with this patient.

When it can be aspirated hairy cells are relatively more numerous than in the blood. The bone marrow biopsy shows infiltration that may be interstitial in a hypocellular marrow - as in our case - focal or diffuse with a highly characteristic pattern of infiltration.

The characteristic delicate chromatin pattern, and indented or lobulated nuclei are usually readily apparent. Reticulin is usually increased Immunophenotyping has proved very useful in the diagnosis of HCL and in differentiating it from variants and other B-cell malignancies Hairy cells have the immunophenotype of a relatively mature B-cell.

The expression of CD22 is strong. Surface immunoglobulin, and in some cases cytoplasmic immunoglobulins are also expressed. CD10 and CD23 are negative. CD11c is usually positive.

In addition to the B-lineage associated immunophenotypic markers there are also markers with specificity for hairy cells: CD is an integrin, which is also known as mucosal lymphocyte antigen MLA. TRAP activity can also be detected immunologically by using a specific antibody.

Immunophenotypic studies performed on our case revealed a monoclonal lambda B-cell population, with strong CD22 and 11c expression, as well as CD25 expression. This population was also positive for the specific CD marker. Cytogenetic abnormalities described include translocations with a 14q32 breakpoint, del 6 q, monosomy 10, trisomy 5 and monosomy 12 Splenectomy has been the traditional treatment for HCL but is seldom performed anymore.

Splenectomy and alpha-interferon may be still used for HCL under specific circumstances. The prognosis of the disease has improved dramatically since the development of the new nucleoside analogs.

Thirty-five years in the progress of hairy cell leukemia.

Diseases Associated With Benzene Exposure:

Leuk Lymph ; 14 suppl 1: Cordone I, et al. Diagnostic relevance of peripheral blood immunocytochemistry in hairy cell leukemia. Pathol ; 48 Cleary ML, et al.INTRODUCTION. Hairy cell leukemia (HCL) is an uncommon chronic B cell lymphoproliferative disorder (lymphoid neoplasm) characterized by the accumulation of small mature B cell lymphoid cells with abundant cytoplasm and "hairy" projections within the peripheral blood, .

Abstract. To evaluate occupational exposures as risk factors for hairy cell leukaemia (HCL), a population-based case-control study on male HCL patients and .

Hairy cell leukemia case study

Lymphoid granulomatosi Return to top "Lymphomatoid granulomatosis is a rare angiocentric and angiodestructive disease, which commonly involves the lungs but also the brain, kidneys, liver and skin.". Chronic lymphocytic leukemia (CLL) is the most common leukemia and one of the most common lymphoid malignancies in Western countries.

Hairy cell leukemia case study

The pathobiology of CLL is a result of the failure of apoptosis rather than uncontrolled proliferation. By definition, CLL is B-cell. The National Comprehensive Cancer Network (NCCN), a not-for-profit alliance of leading cancer centers devoted to patient care, research, and education, is dedicated to improving the quality, effectiveness, and efficiency of cancer care so that patients can live better lives.

Hairy-cell leukemia is a chronic mature B-cell cancer with unique clinicopathologic and biologic features. Purine analogues (cladribine and pentostatin) induce durable complete responses in.

Chronic Lymphocytic Leukemia: Recent Advances in Diagnosis and Treatment